Endocrine Abstracts

Introduction: Evidence suggests a relationship between high tumoral Ki-67 LI with persistence of tumor after surgery and lower response rate to medical therapy. Therefore, we aimed to determine the relationship between Ki-67 LI and p53 with age, gender, number of surgeries, cure after surgery and cavernous sinus invasion in pituitary adenomas of patients with acromegaly.Methods: The paraffin-embedded tissue sections of 30 patiets with acromegaly, operate...

Introduction: Impaired glucose tolerance and diabetes mellitus are frequently seen complications of acromegaly. Insulin resistance due to chronic growth hormone (GH) excess and inhibition of insulin and glucagon secretion by long-acting somatostatin analogues (SA) used in the treatment are the main reasons of the impaired glucose tolerance.Objective: To determine the effect of long-acting SA treatment on glucose homeostasis regarding the insulin resistan...